ßIG-H3 ELISA

The ßIG-H3 ELISA is designed to measure ßIG-H3 in urine, serum or cell culture supernatant of human or rodent origin. ßIG-H3 (beta-induced H3) is a 68 kD protein induced in diverse cell types by the growth factor Transforming Growth Factor-ß (TGF-ß) that is secreted into the extracellular matrix and is involved in cell growth, differentiation, adhesion, and wound healing. ßIG-H3 expression is altered in various conditions including tumorigenesis, breast cancer, corneal dystrophy, osteogenesis, and atherothrombosis. ßIG-H3 is elevated in the urine of patients with cyclosporine nephrotoxicity and with type 2 diabetes in whom it shows positive correlation with the albumin excretion rate, making it as useful biomarker of renal dysfunction due to diabetes in its earliest phases and in monitoring clinical progression of diabetic nephropathy.